From this point, the Iroquois regard the Delaware as a subserviant people.The Munsee have already separated from the main Delaware group.
Already at war with other Iroquoian tribes, the Wyandots begin to move west.1541 - May 8; Soto reaches the Mississippi River, having marched overland from the Floridas.
The brutal behavior of the Spanish has a devastating effect on the tribes of the southeast; perhaps coincidently, Mississippian culture enters a rapid decline.c.
The Delaware still on the Susquehanna stay neutral at first.
Fort Duquesne (the present Pittsburgh) is built by the French where the Allegheny and Monongahela Rivers join to form the Ohio.
Petun and Huron refugees leave Ontario, and spend the winter of 1649-50 on Mackinac Island.c.