Cam4 usa adult


Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of mi R-320 into endothelial cells.

Cam4 usa adult-6

NIHMSID: NIHMS595036 Pub Med [journal] PMID: 24825548 PMCID: PMC4120246 Yue X, Yang X, Lin X, Yang T, Yi X, Dai Y, Guo J, Li T, Shi J, Wei L, Fan G, Chen C, Chang J. Loss of duplexmi R-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis. NIHMSID: NIHMS561798 Pub Med [journal] PMID: 24486439 PMCID: PMC3959587 Surma M, Handy C, Chang J, Kapur R, Wei L, Shi J. PMID: 2 4595357 PMCID: PMC3942480 2013 Lin X, Liu B, Yang X, Yue X, Diao L, Wang J, Chang J.

Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure. ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment. Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling. Pub Med PMID: 24058688 Pub Med Central PMCID: PMC3772891.

2016 Baohui Liu, Huimin Dong, Xi Lin, Xiangsheng Yang, Xiaojing Yue, Jian Yang, Yuntao Li, Liquan Wu, Xiaonan Zhu, Shenqi Zhang, Daofeng Tian, Junmin Wang, Qiang Cai, Shanping Mao, Qianxue Chen, Jiang Chang. Yue X, Lin X, Yang T, Yang X, Yi X, Jiang X, Li X, Li T, Guo J, Dai Y, Shi J, Wei L, Youker KA, Torre-Amione G, Yu Y, Andrade KC, Chang J. NIHMSID: NIHMS746184 PMID: 26756630 Liu B, Lin X, Yang X, Dong H, Yue X, Andrade KC, Guo Z, Yang J, Wu L, Zhu X, Zhang S, Tian D, Wang J, Cai Q, Chen Q, Mao S, Chen Q, Chang J. Genetic deletion of Rnd3/Rho E results in mouse heart calcium leakage through upregulation of protein kinase A signaling. SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy Journal of Molecular and Cellular Cardiology 2015; 4-64.

RND3 promotes Snail 1 protein degradation and inhibits glioblastoma cell migration and invasion. Rnd3/Rho E Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis. Downregulation of RND3/Rho E in glioblastoma patients promotes tumorigenesis through augmentation of notch transcriptional complex activity. Pub Med [journal] PMID: 25128087 2014 Wang X, Huang W, Liu G, Cai W, Millard RW, Wang Y, Chang J, Peng T, Fan GC.

The focus of my lab is to understand the molecular mechanisms that initiate and mediate the pathogenesis of maladaptive cardiac remodeling, such as cardiac hypertrophy and fibrosis. PMCID: PMC4567025 Kim EY, Zhang Y, Ye B, Segura AM, Beketaev I, Xi Y, Yu W, Chang J, Li F, Wang J. Protective effect of radix salviae miltiorrhize on ethanol-induced gastric mucosal damage in rats and mechanism.