One out of every two thousand children in America is born intersexual (125,000 living in the United States today--enough to fill a good sized city).
However, this is not to say that all persons with those nakshatras are hermaphrodites, yet studies have found that many of hermaphrodite nakshatras do indeed have a tendency toward either genital deformity (mal-formed, excessively large or small genitalia) etc. When they rise to follow the regulative principles of the Kanistha adhikari then their status changes to aspiring to be Transcendentally Situated.
So some might say that more than Tritiya Prakriti (three sexes) there are in fact Pancha Prakriti (five sexes); 1/. The above point is very important in keeping the sanity of the parampara, and not cheapening the worth and quality of being factually detached from mundane bodily inclinations.
The Ordinary devotee often just goes along with life unable or un-desirous of understanding that they are different from their body, its demands, and dictates, and often gives in to those demands.
The Ka-nistha (un-steady) adhikari struggles with becoming situated in the Transcendental status, and with good association, and regulating practical service to the Lord and the devotees in time one can become fixed and gain a taste.
Such combinations might make a person with a male body have soft nature of a female nakshatra such as Swati or Sravan, or Dhanistha, and similarly one born with a female body might have male inclinations due to such Janma nakshatras as Pushyami, Purva Bhadrapad, or Hasta. Certainly devotees may come from any walk of life, but the clear seeing Acharya Srila Bhaktivinod Thakur openly declares in his Sri Chaitanya Shikshamrita that there are two kinds of devotees, the Ordinary Devotee, and the Transcendentally Situated devotee.