In late April 2005, she also took part in the annual Broadway Cares’ Easter Bonnet Competition, being sawed in half by a magician in their Clearly Impossible sawing illusion.
Sweet Charity ended its Broadway run on December 31, 2005.
She is also known for voicing Brittany in the Alvin and the Chipmunks film series.
Applegate guest-starred in 21 Jump Street (1988) and Top of the Heap (1991, as Kelly Bundy), and hosted Saturday Night Live (May 8, 1993, and October 13, 2012) and MADtv (1996).
The character of Sue Ellen Crandell in the black comedy feature Don't Tell Mom the Babysitter's Dead (1991) was Applegate's first starring role in a mainstream film, playing a rebellious teenager who is forced to take care of siblings after their summer babysitter dies. with Children was cancelled in May 1997, Applegate starred as Claudine Van Doozen in the independent feature Claudine's Return (or Kiss of Fire), was cast in the action-comedy The Big Hit, and played the fiancée of a mob descendant in the Mafia satire Jane Austen's Mafia (1998).
In 1986, Applegate won the role of Robin Kennedy (1986–87), a policeman's daughter, in the police drama series Heart of the City.
Meanwhile, she was also seen guest starring in several other television series such as All is Forgiven, Still the Beaver, Amazing Stories, and the Family Ties episode "Band on the Run" (1987) as Kitten.
In 1987, Applegate played the role of the ditzy, sexually promiscuous daughter, Kelly Bundy, on the Fox Network's first sitcom, Married... She portrayed her character for 11 years (1987–97).