Most of the time, medications do not entirely eliminate symptoms but provide symptom reduction and could be more effective when used in conjunction with an ongoing program of trauma specific psychotherapy for patients, such as PE or CPT (14).
Each case of posttraumatic stress disorder (PTSD) has unique biological, psychological, and social determinants with differing treatment implications.
Medications can be used to ameliorate the biological basis for PTSD symptoms along with co-occurring psychiatric diagnoses, and indirectly may benefit psychological and social symptoms as well.
Back to top The biological disturbances in PTSD can be conceptualized as a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and the balance between excitatory and inhibitory brain neurocircuitry.
There is a resultant dysregulation of adrenergic mechanisms that mediate the classical fight-flight or freeze response.
Trials which are randomized, placebo-controlled, and double blinded are the gold standard for guiding pharmacotherapy decision making.