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Sex differences in the response to estrogen in this nucleus may therefore underlie sex differences in the display of receptive behavior.

The VMH sex differences described are similar to those in rats in that females exhibit estrogenic regulation of ER- and PR-m RNA while males do not, suggesting that this pattern is evolutionarily conserved.

Neither sex nor treatment effects were definitively shown for ER- or PR-m RNA abundance in the anterior hypothalamus-preoptic area.